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Models and simulation techniques for discovering diabetes influence factors

Studies and data bases across Europe


● VIVA (study): aimed to describe the most frequent cardiovascular risk factors (CVRF) clustering related to the metabolic syndrome (MS) in a non-diabetic cohort. Estimates the probability of developing T2DM and IGT during 10 years in subjects free from these anomalies (NGT).

● ePREDICE (study): To compare the effect of 3-year treatment with sitagliptine, metformin or a fixed-dose combination plus lifestyle intervention (diet and exercise), to lifestyle intervention alone on different microvascular parameters (retinal, renal and neurological) in adults with pre-diabetes (IGT, IFG, or both).

● Healthy Breakfast (study): To design an standard breakfast as a substitute for the OGTT, to be performed at home. To elaborate an algorithm for the automatic diagnosis of dysglycaemia in patients with high risk using a CGM system.

● OpT2mize (study): Study to assess continuous subcutaneous insulin infusion (CSII) in diabetes type 2. 400 patients are being managed using Carelink iPro2 to collect blinded CGM data in order to obtain more than HbA1c as endpoint.

● Carelink (study): Database storing information from almost 7500 T1DM (80%) and T2DM (20%) subjects in Europe.

● GECHRONIC (study): Study on remote management of complex chronic patients, including remote monitoring. Data from 90 complex chronic patients of Valencia Health Agency in one year of monitoring.

● La Fé (hospital database): Database of clinical data retrieved during the daily activity in the Health Department, including hospital and primary care. Population covered by the department is around 200,000 inhabitants.

● Managed Outcomes (study): Healthcare processes for diabetes patients in primary care. 2000 T2DM patients from Valencia Health Agency.


● FSM (hospital database): Database of clinical data retrieved during the daily activity in the Diabetology Ambulatory.

● ASL Pavia (administrative database): Continuous Integration Data Warehouse of both clinical (1.020) and administrative data (2.020) of T2DM patients in Pavia, Italy.


● Hyppokration Hospital of Athens (Hospital Database). It tracks the continuous follow-up of 560 type 2 diabetic patients.


● BOTNIA (PPP and BPS) (studies). The Botnia study includes today approx. 10,000 individuals from 1400 families. Of them, about 3400 have diabetes and 1000 have IGT or IFG. Around 2800 non-diabetic individuals have been prospectively followed during a mean time of 8 years (the Botnia Prospective Study). The PPP–Botnia study is a population-based study designed to obtain accurate estimates of prevalence and risk factors for diabetes, impaired glucose tolerance and the metabolic syndrome.

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