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Models and simulation techniques for discovering diabetes influence factors

Partners

MOSAIC project consist of 10 Partners from 5 EU member states (ES, IT, GR, FI, SE):

Medtronic is a worldwide leading medical technology company with a wide range of CE marking, and FDA approved products and therapies in the diabetes field such as Continuous Glucose Monitors, Diabetes Management Software (CareLink) and Insulin Pumps With CGM. i.e. Guardian Real Time; iPro2 and insulin therapy delivery Paradigm Minimed and Paradigm VEO, the only medical device approved by the FDA that combines continuous glucose monitoring and insulin delivery.

Since 2008 the company has adopted a global strategy for R&D, extending its research centers to new locations in Europe like Spain, from where there is a special focus on the development of services and platforms for the diagnosis and management of chronic diseases.

Medtronic also treasures expertise in subcutaneous diagnostic systems and clinical research along with a fluent relationship with key opinion leaders and experts in the diabetic field.

The University of Padova is one of the oldest universities in Europe, and one of the biggest in Italy. The University has more than 60 departments in almost all the disciplines and the research areas. There are about 57 thousands of students, and about 6 thousand graduate every year. The Department of Information Engineering is one of the biggest departments. It is a leading centre for education, research and technological development in the area of electronics, quantum physics, automatic control, photonics,telecommunications, computer science, instrumentation and measurement, operation research and bioengineering. It has 90 Professors (38 full, 25 associate, 27 assistant) and 117 PhD students and Research Fellows. Partner in the project is the Bioengineering Group, which includes 10 faculty members (2 Full Professors, 3 Associate Professors and 5 Assistant Professors), 8 post-doc fellows and 20 PhD students.

Life Supporting Technologies (LifeSTech) is a research, development and innovation group, part of the Technical University of Madrid (Universidad Politécnica de Madrid). Its activities are devoted to the design, development and evaluation of ICT based services and applications, for the creation and promotion of new ideas, methods and technological solutions throughout the value chain of e-Health and e-Inclusion related organizations.

LifeSTech is one of the main Spanish research groups in the field of e-Health. The main group skills include consultancy, design, development and evaluation of ICT applied to Health, Ambient Intelligence, Technological Architecture, Business Process Engineering, and System Development and Integration. The LifeSTech professionals are regarded as specialist in the international scene in the field of ICT applied to Health and Social sectors. Both past and current R&D projects funded by several national and European private and public research programs endorses LifeSTech experience, and a significant number of articles and papers that contribute to the dissemination of the results obtained in the different research areas. LifeStech has been Technical Manager of the METABO project, involved in the definition of the disease management tools for collecting clinical, lifestyle and environmental variables and coordinated the validation of the exploratory clinical trial.

LifeStech has been Technical Manager of the METABO project, involved in the definition of the disease management tools for collecting clinical, lifestyle and environmental variables and coordinated the validation of the exploratory clinical trial.

The Biomedical Informatics Laboratory “Mario Stefanelli” (BMI) is part of the Department of Industrial and Information Engineering of the University of Pavia, one of the oldest universities in Europe and the oldest in Lombardy. Created in 1982 and today directed by Prof. Riccardo Bellazzi, BMI is an important center both for training and for research and development of innovative ICT (Information & Communication Technologies) applications in the health care domain. Nowadays about thirty people are working at BMI, focusing their activity on two different research areas: BioInformatics and Data Mining Group and Medical Informatics Group.

The BMI BioInformatics and Data Mining Group has a noteworthy experience in the fields of Bioinformatics, Clinical Data Mining and Biological Knowledge Management. This group has strong expertise in developing advanced methods and tools for supporting clinical data analysis, molecular medicine and translational research, with a focus on decision support. In particular, the lab is currently developing software solutions for clinical and –omics data analysis, intelligent querying of the phenotype data, integrated search on biological data and knowledge repositories, text mining of the relevant literature.

The research activities carried out by the Medical Informatics Group have led to a number of significant accomplishments in the areas of decision support systems, artificial intelligence, man-machine interfaces, web-based and telephone-based systems. BMI is also strongly involved in designing and developing computer systems supporting the processes of prevention, diagnosis and treatment. These systems integrate a wide range of methodologies, including: economic evaluation of health strategies; Artificial Intelligence techniques and methods for defining and managing computerized guidelines; Advanced voice-interfaces; Wearable systems for patient’ monitoring during the rehabilitation.

In Pavia the Fondazione Maugeri Internal Medicine and endocrinology Unit also provides patients with cutting edge diagnostic/treatment pathways for some complex conditions which are mainly linked to changes in the endocrine system and metabolism, by integrating intervention from other Units. In particular, activity specializes in study, prevention, diagnosis and treatment of:

● Diabetes and chronic complications

● Obesity and food behavior disorders

● Thyroid dysfunction and tumors of thyroid

● Hypophysis disease

● Osteoporosis

● enopausal conditions in the context of endocrine/gynecological outpatient treatment

● olysystemic and autoimmune conditions

The working relationship between the Unit and adjoining sectors in rehabilitation, Nuclear medicine, Pathological anatomy, Oncology, Pain Therapy, Plastic Surgery and Endocrine Surgery is key in treating diabetes, obesity and conditions of the thyroid. Structured translational programs are co-ordinated and shared between these departments.

Our group has the experience both in the field of Epidemiology and Prevention of Diabetes and CVD in elderly people. During the past decades and years we have ensambled a large population-based cohort (10-year follow-up) of elders (n=3500) in Spain (The EPICARDIAN Study), and have developed an specific risk score, including info about diabetes status, for people older than 65 years. Also DE-PLAN 70+ Project is ongoing in the second year follow-up in Spain. We are validated as a non-profit research association by the FP7.

The Lund University members are part of the Lund University Diabetes Centre (LUDC), which is an academic research centre founded in 2006 on a 10-year grant for selected research environments from the Swedish Research Council. It has locations in Malmö (Clinical Research Centre) and Lund (BioMedical Centre) and provides the LUDC researchers with excellent, state-of-the-art laboratory and animal facilities.

LUDC is among the largest diabetes research centres in the world and combines the expertise of 20 principal investigators, each adding their specific knowledge to the Centre and covering most diabetesrelevant research topics, from genetics to islet function and diabetic complications, both in type 1 and T2DM. The Centre comprises a staff of some 260 persons, of whom 45 are senior scientists, ∼60 postdoctoral fellows and 65 PhD students.

TSB was founded in February 2008 as a spin-off of the ITACA Institute of the Polytechnic University in Valencia. With over ten years of research experience for the healthcare sector and thanks to the its structure and alliances, TSB is able to evaluate effectively and take advantage of the business potential which arises from the most relevant R&D results in this field, introducing into the market innovative solutions and products which meet each client needs.

The prime objective of TSB Tecnologías para la salud y el bienestar is to create and develop innovative solutions and products for the healthcare sector. Our company aims to satisfy the needs related to health, E-inclusion and improving quality of life by using the latest technologies. In particular TSB develops products and services in areas that range from systems for home hospitalization and managing chronic illness, to services and systems for sport, free time activities or ambient intelligence.

Samfundet Folkhalsan is a Swedish-speaking non-governmental organization in the social welfare and health care sector in Finland. It carries out scientific research and provides social welfare and health care services as well as information and counseling in order to promote health and quality of life. Research activities of the Folkhalsan Research Center is involved in research on genetics, preventive medicine and public health

The Botnia Study (www.Botnia-Study.org)is a collaborative project of the Folkhalsan Research Center and University of Helsinki in Helsinki, Finland, Lund University in Sweden and five municipal health care centers in Western Finland.

The National Technical University of Athens is the oldest and most prestigious educational institution of Greece in the field of technology. The history of the NTUA goes back to 1836, when the Royal School of Arts, ancestor of the NTUA, was founded. NTUA took its present form in 1917. NTUA is divided into nine academic Faculties, eight being for the engineering sciences, including architecture, and one for the general sciences. The personnel of the nine faculties includes more than 700 people as academic staff, 140 scientific assistants and 260 administrative and technical staff. The total number of NTUA employees is about 1350. The total number of undergraduate and graduate students is about 8500 and 1500, respectively. The undergraduate degree in NTUA is a 5 years program leading to a Diploma, while graduate studies in NTUA lead to a Ph.D. degree. Scientific research in NTUA is funded by both the public and private sectors, as well as by European Union sources. The Faculty of Electrical and Computer Engineering (FECE) covers the areas of electric power systems, telecommunications systems, applications of electronics in various scientific fields, and computer engineering and science. Presently, there are 55 Professors, 10 Associate Professors, 12 Assistant Professors and 5 Lecturers in FECE. The FECE has extensive experience in the management of large scale research projects. The annual research budget of the Faculty is about 10 Million €. The Biomedical Simulations and Imaging (BIOSIM: http://www.biosim.ntua.gr/) Laboratory, part of the FECE, is involved in research and has extensive experience mainly in the following areas: biosignal processing and analysis, computer aided diagnostic systems and treatment, simulation and modeling of complex biological / physiological processes, neuroinformatics / computational neuroscience, medical applications and safety issues of electromagnetic fields. Over the last years, the BIOSIM has been involved in a number of Greek and EU funded projects.

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